Ken Miller

Opponent inhibition: A developmental model of layer 4 of the neocortical circuit

University of California, San Francisco

We have previously introduced a simple model for the circuitry of layer 4, the input-recipient layer, of cat primary visual cortex (V1). In this model, simple cells receive input from the lateral geniculate nucleus (LGN) in a "Hubel-Wiesel" pattern: ON-center inputs have centers overlying the simple cell's ON-subregions, and OFF-center inputs overly OFF-subregions. Cells receive strong opponent or "push-pull" inhibition from inhibitory neurons driven by the opposite pattern: if cell A inhibits cell B, then cell A tends to have OFF(ON) subregions overlying ON(OFF) subregions of cell B. A cell receives excitation from other cells preferring similar patterns to the cell's own preferred stimulus. We summarize this as "correlation-based" circuitry: excitatory cells tend to project to cells preferring similar stimuli, while inhibitory cells tend to project to cells preferring roughly opposite stimuli. We have shown that this circuit can explain many attributes of simple cell orientation tuning including the contrast-invariance of this tuning (Troyer et al.,1998); can explain the low-pass temporal frequency tuning of cortical cells (Krukowski and Miller, 2001); and can explain a variety of contrast-dependent response nonlinearities that have previously been proposed to require a nonspecific "normalizing" inhibition (Kayser et al., 2001; Lauritzen et al., 2001).

We now show that this circuit -- both the LGN and the intracortical connections -- will self-organize under simple Hebbian rules of activity-dependent synaptic modification. This leads to the hypothesis that layer 4 of cortex more generally may develop under simple Hebbian rules, and that opponent inhibition -- generalized to mean inhibition driven by the input pattern most anticorrelated with the pattern that excites a cell -- may be a general property of cortical layer 4. Just as opponent inhibition can endow layer 4 of cat V1 with contrast-invariant orientation tuning, we suggest that more generally the development of opponent inhibition leads layer 4 of any piece of cortex to have magnitude-invariant form recognition: the ability to respond to a preferred pattern of input even at very low stimulus magnitude, while not responding to a partially overlapping pattern of input even at high stimulus magnitude.
Friday, February 23, 2024
About the Swartz Foundation...
 
The Swartz Foundation was established by Jerry Swartz (bio) in 1994 . . .
more>
 
Follow us...
 
The Swartz Foundation is on Twitter: SwartzCompNeuro
more>
 
 
2013 Stony Brook Mind/Brain Lecture - Michael Wigler, PhD
 
 
2012 Stony Brook Mind/Brain Lecture - John Donoghue
 
 
Sloan-Swartz Centers Annual Meeting 2011
 
 
2011 Stony Brook Mind/Brain Lecture - Allison J. Doupe
 
 
2011 Banbury Workshop
 
 
Sloan-Swartz Centers Annual Meeting 2010
 
 
2010 Stony Brook Mind/Brain Lecture
 
 
Sloan-Swartz Centers Annual Meeting 2009
 
 
Conference on Neural Dynamics
 
 
2009 Stony Brook Mind/Brain Lecture
 
 
Canonical Neural Computation, April 2009
 
 
2009 Banbury Workshop
 
 
Sloan-Swartz Centers Annual Meeting 2008
 
 
Theoretical and Experimental Approaches to Auditory and Visual Attention - Banbury 2008
 
 
Stony Brook Mind/Brain 2008: Patricia Smith Churchland, B. Phil. D
 
 
Sloan-Swartz Centers Annual Meeting 2007
 
 
New Frontiers In Studies Of Nonconscious Processing - Banbury 2007
 
 
Stony Brook Mind/Brain 2007: Professor Michael Shadlen, MD, PhD
 
 
Multi-level Brain Modeling Workshop 2006
 
 
Sloan Swartz Centers Annual Meeting 2006
 
 
Banbury 2006: Computational Approaches to Cortical Functions
 
 
Stony Brook Mind/Brain 2006: Helen Fisher -- Lecture Videos
 
 
Sloan-Swartz Centers for Theoretical Neurobiology
 
 
Swartz Center for Computational Neuroscience
 
 
Banbury Center Workshop Series
 
 
Other Events
 
www.theswartzfoundation.org                           Copyright © The Swartz Foundation 2024